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It seems that Alexandrov's [structural variant and copy number signatures][1] estimated by the [SigProfiler software ecosystem][2] aren't c…
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Then you may want to see if a program like `lastz` ([**LINK**][1]) may be useful.
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Can you try this?
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Thank you for the response but it does not change anything.
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I have not tested but you could try something like below-
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