Hello! I am using Control-FREEC to detect Mb long CNV from single cells sequenced at LP-WGS (average coverage 0.1X or less). Considering the ultra-low coverage used in this setting (0.1X), no structural variants (SV) other than CNV could be predicted and there is no advantage in using paired-end; accordingly, we decided to use single-end reads. Does anybody have an idea of possibile advantages in using paired-end reads in these setting? Thank you a lot! AM