Also see http://www.nature.com/news/scientific-method-statistical-errors-1.14700 for some insights on how to interpret P-values. One of the most striking remarks is the effect of sample size, that is, how you could get significant values with many data points comparing two distributions, although the difference between the means is tiny.
Looking Review Paper About P-Value, Adjusted P-Value And Multiple Test In Bioinformatics
4 answers
This may be somewhat tangential to your exact question, but you could start by looking at the series "Points of Significance" in Nature Methods (https://www.google.com/search?q=Points+of+significance).
They have a nice overview of some important ideas. E.g.: http://www.nature.com/nmeth/journal/v10/n11/full/nmeth.2698.html
There's not one explicitly about multiple-testing yet, but I suspect it won't be long.
It's not a journal article per se, but the book Intuitive Biostatistics by Harvey Motulsky provides an excellent overview of the concept of a P value in its first section, and then dedicates a section to the P value wherein he goes into about as much detail as you could possibly want.
There is also 'How does multiple testing correction work?' (Noble, Nature Biotech, 2009)
Andreas
What about p-value misuse? A Dirty Dozen: Twelve P-Value Misconceptions (2008) Steven Goodman, Seminars in Hematology
• 141 views
•
link
written
by
Frédéric Mahé
Log in to answer this question.
More posts like this
-
Pooling biological replicates and accuracy of differentially expressed genes analysis from RNA-seq …
written by seta
-
Looking for a review paper on Transcriptomics ? (Recommendation)
written by tevlon84 •
-
comprehensive assessment of isoform quantification accuracy from RNASeq data: How much it can be wr…
written by jack
-
what is the best p value cuttoff to select differentially expressed genes ?
written by jack
-
How to write effective and stable bioinformatics pipeline in R ?
written by jack
-
Looking review paper about; From mapping NGS reads to quantification of gene expression
written by jack
-
Forum: Looking For Bioinformatics Job In Germany
written by jack •
-
State Of Art Bioinformatics Works For Microrna Functions In Different Cancers.
written by jack •
-
Over Representation Vs Enrichment Analysis
written by jack •
-
State-Of-The-Art Of Rna Structure Prediction Algorithms
written by tomas.iesmantas •
