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How to calculate 4DTv distance (D4DTv) that stands for fourfold synonymous third-codon transversion ?

Hi guys,

I have a multiple sequence alignment and I need to calculate 4DTv distance (D4DTv) that stands for fourfold synonymous third-codon transversion. I wonder if there is a program which can calculate it or a function in R?

Thanks

gene codon

Do you have an answer to your question? I'm doing it now and it is not easy to find people who did it already.

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