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What are the advantages of using cell-lines over tissue samples of RNA-seq data ?

Hi,

I am working on the cancer samples, it includes the both cell-line samples as well as tissue samples of rna-seq data, and task is to identify differentially expressed genes.

What are the advantages of cell-line samples in contrast to tissue samples?

Please share any papers or articles can explain about advantages of cell-lines?

cell-line rna-seq

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