Dear biostars,

I am generating some synthetic sequencing files to benchmark my WES based CNV detection pipeline. I have generated a synthetic genome with simuG and am generating synthetic read files using ART with the code below.

art_illumina -ss HS20 -sam -i $genome -p -l 100 -f 20 -m 150 -s 10 -ir -dr -o $name

This creates a very detailed genome, but is there a way I can adjust the parameters to generate WES data instead?

Also does anyone have any advice on how to use ART in a way to generate more sporadic read depths across the genome? This would better simulate the quality of real-world data I am benchmarking by CNV detection pipeline for.

Cheers