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Assembly of 2 different illumina read lengths

Hello, I'm trying to do de novo assembly using illumina 2x150 reads. I also have Illumina 2x300 reads for the same sample. Can I use two different read lengths in assembly and if so how can I do that. Which tools are preferred in this regard? Any suggestions are welcome. Thank you

different assembly illumina lengths

1 answer

You can use SPAdes. Check the manual to see how to use multiple illumina PE libraries

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