Lowercase Characters In Sequenced Genomes
I am wondering if there is any special meaning of lower case a,t,g,c in the sequenced genomes.
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That's called "soft masking". Generally, these were found to be repeat regions with RepeatMasker (or some other tool). There are a couple options when it comes to masking genome. Aside from soft masking, one can "hard mask", meaning replacing a given region with a bunch of N's. This, of course, can produce pretty useless genomes for many use cases. Consequently, you'll often find people keeping soft-masked genomes around (I recall that UCSC provides both, with the regular genomes that you download already being soft masked).
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