This is a test version of Biostars. For the public version, visit https://www.biostars.org.
Simulating Trio Data

Which tool could be used to generate/simulate parents-offspring whole genome sequences (human) in accordance with a specified recombination rate?

trio genome simulation
• 1,672 views • link
updated by Len Trigg Len Trigg • written by Ritu • Ritu

1 answer

You could use the simulation tools available in RTG Tools. I would recommend running the demo-tools.sh script that comes as part of the package, as that steps through an end to end simulation of genomes of family members. You can then modify things from there according to your needs. In particular rtg childsim has the ability to adjust the overall recombination rate via --num-crossovers

• 1 views • link
written by Len Trigg Len Trigg

Thanks for the reference. I would try the tool's simulation.

• 1 views • link
written by Ritu • Ritu

Log in to answer this question.

More posts like this