Hi,
The question is not clear for me. But you can refer to this paper Cancer biomarkers. In sections Identification of a potential biomarker and Steps in the development of a candidate biomarker. The paper it self is old but it will give you good start.

~Best

Just like a previous thread ( How to identify Disease biomarkers " DNA sequences as biomarkers " ) this question is poorly explained and it's very hard to understand what you are looking for. Please spend some more time explaining your question(s).

I gave a comprehensive answer about how one could identify 'cancer signatures' via lasso-penalised regression here: A: How to exclude some of breast cancer subtypes just by looking at gene expressio

Vague question = Vague answers though