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how to define new discovered genes from list of genes?

hello guys,

If i define a list of genes by applying some machine learning or any regularization methods, if we say i get 200 genes. From those 200 genes, i find 50 genes existed in the literature, or even by applying cross validation and define that those genes are significant, what about the others and how i can validate them or considered them as new genes in my study ? So my main question is how to define newly discovered genes from my this list or how to judge that these genes are new genes obtained in my study? Do i need any statistical tests or any method ??

I appreciate any help please!

genes genome machine learning new genes
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written by Chaimaa Chaimaa

what about the others and how i can validate them or considered them as new genes in my study ?

That really can only be done by experimental methods.Sounds like you have tried to find evidence for them by blast and failed to find homologs?

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written by GenoMax GenoMax

@genomax hi genomax, can you give me more details please, experimental methods like what ? !, no i didnt apply blast how it can be applied in this issue it can be?

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written by Chaimaa Chaimaa

Like doing RNAseq, RACE assays, cDNA libraries etc. These are all experimental techniques. You can only go so far with predictions/informatics approaches in hypothesis generation. Those hypothesis then have to be tested independently in lab.

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written by GenoMax GenoMax

got it @genomax, Thanks a lot!

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written by Chaimaa Chaimaa

any other help please?

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written by Chaimaa Chaimaa

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