This is a test version of Biostars. For the public version, visit https://www.biostars.org.
Mapping Protein Mutation to Genomic DNA

Hi,

We have specific protein mutations and we are searching for tools to map these protein mutations to the exact location on the genomic DNA.

Do you have any suggestions ?

Thanks

protein mutation genomic

1 answer

The short answer is you can't, because the amino acid code is degenerate. The long answer is, you can get close, if you're willing to make assumptions about the specific transcript being used and guess at which mutation caused a specific AA change, as there are several different possibilities.

There are many previous questions about this (here is one: https://www.biostars.org/p/15992/)

The best tool I'm aware of is Transvar

Thanks for the suggestions Chris Miller.

Log in to answer this question.