How to calculate the depth of coverage on a BAM file generated from Pacbio Targeted Longread sequencing? In short-read paired-end sequencing, GATK DepthofCoverage gives the …
> I have haplotypes (CYP2D6.1, CYP2D6.2, CYP2D6.3, CYP2D6.4, CYP2D6.5, > CYP2D6.6) How do I calculate the haplotype frequencies these haplotypes in 1000 genome populations?
1) What is the overarching challenges in the assembly algorithms? 2) How different algorithms handle local repeats or segmentation duplicates in the genome? 3) How …
Maybe this publication will help? - https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-6-245