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Relationship between conserved genes and SNP calling

hi,

supposing a list of ortholog genes between human and mouse, how SNPs can help to identify variations? in the other word why we need variant calling in evolutionary genomics?

thank you

snp evolutionary genomics genome sequencing gene
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updated by Ram Ram • written by zizigolu zizigolu

SNPs don't help identify variations. SNPs are variations. Perhaps you could rephrase the question?

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written by Brian Bushnell Brian Bushnell

thank you Brain, actually I mean (as I noticed in literatures) for example why in a list of ortholog genes between two organisms we perform variant calling? how SNPs help in evolotionary process in these orthologs

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written by zizigolu zizigolu

I'm a software developer, not a biologist, so please don't consider this definitive. But you can use SNPs to trace evolution. Let's say you have 5 organisms, A, B, C, D, and E. If D and E share a SNP, then presumably, they arose from a common ancestor (in practice, this would be a function of the number of SNPs they share, rather than a single SNP). If C, D, and E share SNP s1 but only D and E share SNP s2, then presumably C is a common ancestor of D and E, but then at some point they diverged from C (gaining SNP s2) and subsequently diverged further but retained s2. A and B in this case would have neither s1 nor s2 and thus be more distantly related.

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written by Brian Bushnell Brian Bushnell

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