Relationship between conserved genes and SNP calling
hi,
supposing a list of ortholog genes between human and mouse, how SNPs can help to identify variations? in the other word why we need variant calling in evolutionary genomics?
thank you
snp
evolutionary genomics
genome
sequencing
gene
0 answers
No answers yet.
Log in to answer this question.
More posts like this
-
News: Online course — Comparative Genomics — 7–11 April
written by Physalia-courses 281We are pleased to announce that a few seats remain for the upcoming Physalia online course: Comparative Genomics. ---------- Dates: (online) 7–11 April ---------- > …
-
Finding a gene in human
written by zizigolu 438Hi I my mouse model, I have observed a novel gene carrying an individual interesting variant only in cases mice not controls. How I locate/mine/find …
-
How to get orthologs between Two species in orthodb
written by hemantcnaik 0Hello I wanted a species specific ortholog genes between human and mouse through orthodb how can I get? can Any one suggest me, I have …
-
tool to identify genomic structural variations in completely sequenced prokaryotic genomes
written by anwesha.mohapatra11 0Hi , I want to identify genomic structural variations on prokaryotic genomes. I came across a tool Mugsy which can identify indels and genomic re-arrangements..However …
-
Predicting phenotype based on the expression of genes
written by zizigolu 438Hi, Supposing we have measured cholesterol level in control and treated mice (treated by a drug). We also conducted microarray between control and treated mice. …
-
Identifying genes that are regulated under negative feedback
written by zizigolu 438Hi, As I understood, by computing individual adjusted p-values between each gene (RNA-seq) and polymorphisms in its vicinity (genotyping), then selecting the highest association, we …
-
finding a list of genes involved in a pathway?
written by zizigolu 438hello, how can I take a list of genes involved in angiogenesis in human? thank you
-
extracting targe genes of a list of TFs
written by zizigolu 438hi, supposing a list of TFs and their targets as below > head(tf2target[,1:2]) TF gene 1 AHR 1/2-SBSRNA4 2 AHR A4GALT 3 AHR AAMP 4 …
-
retrieving all Human Mouse between species out-paralogs
written by Moses 15<p>Hi,</p> <p>I want to collect all the pairs of paralogous genes between human and mouse. i.e. human mouse between species out paralogs. I was able …
-
How Can I Find The Conserved Microrna Genes Between Human And Mouse
written by K-Li 8<p>Hi,BioStar!I want to find the conserved microRNA genes between human and mouse. How can I do it? some published data or how to high throughput …
SNPs don't help identify variations. SNPs are variations. Perhaps you could rephrase the question?
thank you Brain, actually I mean (as I noticed in literatures) for example why in a list of ortholog genes between two organisms we perform variant calling? how SNPs help in evolotionary process in these orthologs
I'm a software developer, not a biologist, so please don't consider this definitive. But you can use SNPs to trace evolution. Let's say you have 5 organisms, A, B, C, D, and E. If D and E share a SNP, then presumably, they arose from a common ancestor (in practice, this would be a function of the number of SNPs they share, rather than a single SNP). If C, D, and E share SNP s1 but only D and E share SNP s2, then presumably C is a common ancestor of D and E, but then at some point they diverged from C (gaining SNP s2) and subsequently diverged further but retained s2. A and B in this case would have neither s1 nor s2 and thus be more distantly related.