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Finding a gene in human

Hi

I my mouse model, I have observed a novel gene carrying an individual interesting variant only in cases mice not controls. How I locate/mine/find this variant in human?

Thanks for any thoughts

variant gene
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updated by Ram Ram • written by zizigolu zizigolu

1 answer

It is possible that the gene is absent in human, so keep that option open.

Otherwise start looking at the genes in the region of mouse chromosome and then take a look at the corresponding human genome. Start doing some blasting/alignments/inspections.

You will find some pre-computed homology information here: https://www.informatics.jax.org/homology.shtml

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written by GenoMax GenoMax

Thanks a lot

If for instance, this variant is in chr1:114704469..114716771 in mouse genome, if I am following you correctly, you mean in the same position in human genome I should look?

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written by zizigolu zizigolu

You will need to look at the full context. Look for genes around your region to see their concordance in two genomes. Regions may not be in the same location or even on same chromosome.

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written by GenoMax GenoMax

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