Biostar Beta. Not for public use.
Tool/algorithm to assess the effect of several mutations
1
Entering edit mode
17 months ago
roy.granit • 800
Israel/LabWorm

Searching for a tool that could (try to) predict which pathways are predicted to be affected by several mutation co-occurring in a certain tumor..

e.g. mutated PTEN would active the PI3K pathway, and HER2 mutated would also active the MAPK pathway

Thanks!

cancer mutation • 1.1k views
ADD COMMENTlink
4
Entering edit mode
15 months ago
Memorial Sloan Kettering, New York, USA

Here are related tools with varying levels of "ease of use". Good luck!

http://compbio.cs.brown.edu/projects/multi-dendrix/
http://compbio.cs.brown.edu/projects/hotnet2/
http://cbio.mskcc.org/tools/memo/
http://cbio.mskcc.org/tools/netbox/

ADD COMMENTlink
1
Entering edit mode
13 months ago
EMBL Heidelberg, Germany

I would look into Boolean network modelling of pathways. There may be cytoscape plug-ins for this.

ADD COMMENTlink
0
Entering edit mode

Thanks, good idea

ADD REPLYlink
1
Entering edit mode
14 months ago
National Institutes of Health, Bethesda…

netsig is a new one.

ADD COMMENTlink
0
Entering edit mode

Thanks, will check it out..

ADD REPLYlink

Login before adding your answer.

Similar Posts
Loading Similar Posts
Powered by the version 2.1