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protein structure prediction of mutated huntingtin

I need to know whether there exist a secondary, tertiary structure of mutated huntingtin protein? kinly help me with tis

proteins
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updated by Michael Dondrup Michael Dondrup • written by ashamscsoft • ashamscsoft

Can u understand my question. I asked whether there is a structure existing already for mutation sequence

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written by ashamscsoft • ashamscsoft

You'll have to be more specific with your questions when you pose them. You've given us barely any information and expect us to magically know what you are looking for. Be more specific next time. I do not have an answer for you I'm afraid...

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written by Jenez Jenez
Search pdb.org for experimental structures.
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written by Pappu Pappu

In PDB there is a structure for normal sequence. I'm asking for mutated sequence

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written by ashamscsoft • ashamscsoft

2 answers

https://en.wikipedia.org/wiki/List_of_protein_structure_prediction_software

Happy hunting!

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written by Jenez Jenez

You need to understand your biological object of study better and learn to use resources like google, PDB and NCBI, before engaging in more complex tasks.

It took me about 10 seconds to google this:

http://ghr.nlm.nih.gov/gene/HTT

scroll down and find the solution to your question (in paragraph titled "How are changes in the HTT gene related to health conditions?") and why getting a 3D structure of the full mutated protein might be hard. Then you decide to look for the pathogenic fragments and their structure.

Then you look around in PDB entries of huntingtin and also pubmed and find:

http://www.rcsb.org/pdb/explore.do?structureId=3iow

and https://www.ncbi.nlm.nih.gov/pubmed/21910495

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updated by Ram Ram • written by Michael Dondrup Michael Dondrup

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