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What is the way to find the tumor related genes that I find in translocation?

HI.

I have a question. When finding the genes, How can I check the tumor related those genes?

If I find gene A, I want to check which tumor is related with gene A.

Sometimes I search the gene in the COSMIC website and check the study which use the gene.

But this method is so simply...so I want to know certain method.

gene genome
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updated by Ram Ram • written by lee.jingu0626 • lee.jingu0626

2 answers

One of the best approaches for a single gene or a few genes is to search the medical literature using PubMed.

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updated by Ram Ram • written by Sean Davis Sean Davis

Completely agree with Sean Davis, if there are few fusions to analyze the manual literature mining is the best choice.

If there are a plenty of fusions from deep RNA-Seq profiling, I would like to recommend our recent tool Oncofuse. It allows ranking gene fusions based on their probability of being a driver event in cancer. This ranking scheme includes several hallmarks of driver fusions in cancer (see this paper), such as an up-regulation of an oncogene's expression, functional signature, etc. This could be handy if your set includes novel fusions or there are too many fusions to check them manually.

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updated by Ram Ram • written by mikhail.shugay mikhail.shugay

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