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COSMIC CONAN gene expr level

Hi everyone.

I have one question about COSMIC CONAN.

When performing VarScan, I found some region of focal-amplification and I wanted to know which genes are in that region. So I search genes by using COSMIC CONAN.

In CONAN, they shows 'Gene expression' and also Expr level.(Expr level is calculated by z-score)

I confused between lowest expr level gene and highest expr level gene.

Which one is more significant gene in cancer?

gene next-gen

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