PROVEAN usage
Hello, I am a student newly starting bioinformatics.
I was planning to use PROVEAN to predict the impact of amino acid substitutions, but I noticed the web server is down.
I have managed to download the source code, but any tutorials are difficult to find. I have some quick questions:
- Is PROVEAN still a reliable tool for protein function prediction in the current field?
- Since the web service is down, is it better to switch to other tools such as SIFT, PolyPhen-2?
I would appreciate any advice or suggestions. Thank you!
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I don't know PROVEAN but did you try VEP or snpEff ?
I haven't tried VEP but have tried snpEff.
The reason I wanted to try PROVEAN is because it predicts whether a amino acid change affects the protein fucntion and gives a numeric value of the prediction score.
However, snpEff only categorizes its type of amino acid change, rather than predicting the functional change of the protein.