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Tool for within-sample ligand-receptor analysis (bulk RNA-seq) ?

Hi,

this might be a relatively short and (and possibly odd) question, but is there a tool that would be able to determine possible ligand-receptor interactions within a single sample, from bulk RNA-seq data? This would possibly relate more towards identifying things like self-regulation etc.

Any advice (or discussion) is appreciated!

cell-cell communication ligand-receptor self-regulation

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