Hi,

I'm trying to use PRS-CSx which requires SNP, A1, A2, Beta/OR and P value/SE. I want to use the individual study beta's instead of the random/fixed effect. Is there a way to calculate the p value/se for the individual study betas from this information?

Columns in the file:

CHR Chromosome code
BP  Basepair position
SNP SNP identifier
A1  Effect allele
A2  Non-effect allele
N   Number of valid studies for this SNP
P   Fixed-effects meta-analysis p-value
P(R)    Random-effects meta-analysis p-value
OR  Fixed-effects OR estimate
OR(R)   Random-effects OR estimate
Q   p-value for Cochrane's Q statistic
I   I^2 heterogeneity index (0-100)
F0      Individual study beta 1
F1      Individual study beta 2
F2      Individual study beta 3
F3  Individual study beta 4
F4  Individual study beta 5