This is a test version of Biostars. For the public version, visit https://www.biostars.org.
How to Calculate GWAS Summary Statistics?

Hello All,

I have .bed/.bim/.fam files and .pgen/.psam/.pvar files with me How to calculate GWAS Summary Statistics? which data files are useful?

Desired Output:

CHR BP SNP A1 A2 N SE P OR INFO MAF

1 756604 rs3131962 A G 388028 0.00301666 0.483171 0.997886915712657 0.890557941364774 0.369389592764921

2 768448 rs12562034 A G 388028 0.00329472 0.834808 1.00068731609353 0.895893511351165 0.336845754096289

9 779322 rs4040617 G A 388028 0.00303344 0.42897 0.997603556067569 0.897508290615237 0.377368010940814

Where:

CHR: The chromosome in which the SNP resides

BP: Chromosomal co-ordinate of the SNP SNP: SNP ID, usually in the form of rs-ID

A1:The effect allele of the SNP A2: The non-effect allele of the SNP

N: number of samples used to obtain the effect size estimate

SE: The standard error (SE) of the effect size estimate

P: The P-value of association between the SNP genotypes and the base phenotype

OR: The effect size estimate of the SNP, if the outcome is binary/case-control. If the outcome is continuous or treated as continuous then this will usually be BETA

INFO: The imputation information score

MAF: The minor allele frequency (MAF) of the SNP

plink gwas

0 answers

No answers yet.

Log in to answer this question.