I have been having proxy issues with DMRcate (in full detail here: Issues Using DMRcate and rmSNPandCH) and this seems to be in the same vein however, I cannot seem to navigate around this odd error from the following code:

results.ranges <- extractRanges(dmrcoutput, genome = "hg19")
results.ranges

Cannot connect to ExperimentHub server, using 'localHub=TRUE' instead Using 'localHub=TRUE' If offline, please also see BiocManager vignette section on offline use

snapshotDate(): 2023-01-30

Error: File not previously downloaded. Run with 'localHub=FALSE' Traceback:

1. extractRanges(dmrcoutput, genome = "hg19")
2. eh[["EH3132"]]
3. eh[["EH3132"]]
4. .local(x, i, j = j, ...)
5. stop("File not previously downloaded.\n", " Run with 'localHub=FALSE'", . call. = FALSE)

I have tried localHub = TRUE as well as localHub = FALSE and the command still does not work.

For the issue in the link it seemed to resolve when I was on campus where the HPC was - is there a way around this issue in this post? I hope this is enough information?