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predict gain/ loss of function from mutation

Hi, I am using Annovar to group the mutations. However, I need more specific details on gain/loss function of each mutation. I would be thankful if you can guide me how to get such information?

protein mutation loss gain

However, I need more specific details on gain/loss function of each mutation.

what are you missing ?

I want to know the role of missense mutations. So, for each missense mutation, is it loss of function or gain of function?

no idea about my problem?

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