Dear Biostars community,

I am hoping to get a better understanding of sequencing workflows and downstream analysis for DNA encoded chemical libraries (DELs).

I am very familiar with standard RNA-seq, Exome, WGS & ChIP-seq workflows and the various downstream tools like differential expression, variant calling and peak calling respectively but I am completely new to DELs’ NGS downstream processes so I was wondering if there were any good documentations or protocols with the relevant open source tools for DEL NGS analysis…

From my search, it seems that most DEL processes are offered as an end to end solution or package from companies and they perform the analysis in-house. But if I am looking to explore applying other techniques like machine learning or integrate the DEL-seq data with other NGS data, I would like to have some idea of the tools that would allow for such a modular approach.

Thank you and I am looking forward to some guidance and help in this area.