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Penalty for unexpressed genes

Hi all,

I have expression data of two tissues and I have come up with TSI - Tissue specific Index which gives mostly the positive values. My task is looking into this score I should be able to say if the gene is highly expressed or lowly expressed in these two tissues.

Can anyone help me with solving this? I need to know is there any penalty based scoring index or method which can be used to give an solution to the problem by adding penalty to an unexpressed gene?

score penalty

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