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How To Convert Lod Score To P- Value

I have a table of SNPs with their LOD scores from genome wide association mapping. I want to convert these LOD scores to P-value. but I don't know how. any suggestion ?

p-value
• 10,303 views • link
updated by xb xb • written by leila.sharifzadeh • leila.sharifzadeh

1 answer

Dale's conversion helps! You may try out a small piece of R code I wrote, 

lodToPval <-
  function(x)
{
  pchisq(x*(2*log(10)),df=1,lower.tail=FALSE)/2
}

Or using Dale's spreadsheet, genepi.qimr.edu.au/general/daleN/ConvertingLODtoPvalue.XLS

The original paper, http://www.sciencedirect.com/science/article/pii/S0002929707626391

• 681 views • link
written by xb xb

Very helpful to provide both the answer and the citation to the Nyholt review.

• 0 views • link
written by David Quigley David Quigley

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