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How Can One Determine The Significance Of Tajima'S D Scores In A Genome Wide Scan?

I have downloaded a track of genome-wide Tajima's D scores for the human genome, but I do not know how I can specify the significance threshold for these scores? In other words, the question is how confidence limits of D be calculated? Is there any straight forward method for this purpose?

1 answer

Have you tried reading the Wiki page for Tajima's D? It talks about the ways to decide on a cutoff.

Wiki article

This thread was closed because it is repetitive and the answer in the other thread is correct.

Same question

Yes, in the Wikipedia it says:

"Finally, genome wide scan's of Tajima's D in sliding windows along a chromosomal segment are often performed. With this approach, those regions that have a value of D that greatly deviates from the bulk of the empirical distribution of all such windows are reported as significant. This method does not assess significance in the traditional statistical sense, but is quite powerful given a large genomic region, and is unlikely to falsely identify interesting regions of a chromosome if only the greatest outliers are reported."

This is not clear enough, as a it does not define what is a great deviation from the bulk of empirical distribution, and b it does not cite any references.

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