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Is There A Way To Download The Human Exome?

Hi,

Is there a way to get human exome? I will need it for one of my analysis. It is alright if it is bed format or fasta.

Thanks!

human-exome
• 6,201 views • link
updated by Ram Ram • written by Jordan Jordan

"exome sequence"/BED or FASTA ? Please Clarify .

• 1 views • link
written by Pierre Lindenbaum Pierre Lindenbaum

Both BED and FASTA are fine. Editing sequence part.

• 1 views • link
written by Jordan Jordan

1 answer

get the exons as BED:

Exon coordinates of hg19 genome download

extract the FASTA sequences using bedtools getfasta: http://bedtools.readthedocs.org/en/latest/content/tools/getfasta.html

• 122 views • link
written by Pierre Lindenbaum Pierre Lindenbaum

Thanks for the link Pierre. I downloaded this file and I found the length of the exome (sum of all exon lengths) to be 216,018,204 bp. Does it sound right?

• 1 views • link
written by Jordan Jordan

exons overlap. The size of the human exome is ~50M. Use bedtools 'mergeBed' to merge all those exons.

• 126 views • link
written by Pierre Lindenbaum Pierre Lindenbaum

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