Hi all,

I'm trying to get non-synonymous point mutations from COSMIC using COSMICMart, however I don't know how to handle it, cos I'm confused about the definition in COSMIC:

Mutation Type
The mutation type is used to describe the type of mutation that has occurred. :
Substitution : A mutation involving the substitution of a single nucleotide.
Substitution - Nonsense : A substitution mutation resulting in a termination codon, foreshortening the translated peptide.
Substitution - Missense : A substitution mutation resulting in an alternate codon, altering the amino acid at this position only.
Substitution - coding silent : A synonymous substitution mutation which encodes the same amino acid as the wild type codon.
Substitution - intronic : A substitution mutation outside the coding domains. No interpretation is made as to its effect on splice sites or nearby regulatory regions.
Insertion : An insertion of novel sequence into the gene.
Insertion - In frame : An insertion of nucleotides which does not affect the gene's translation frame, leaving the downstream peptide sequence intact.
Insertion - Frameshift : An insertion of novel sequence which alters the translation frame, changing the downstream peptide sequence (often resulting in premature termination).
Deletion : A deletion of a portion of the gene's sequence.
Deletion - In frame : A deletion of nucleotides which does not affect the gene's translation frame, leaving the downstream peptide sequence intact. 
Deletion - Frameshift : A deletion of nucleotides which alters the translation frame, changing the downstream peptide sequence (often resulting in premature termination).
Complex : A compound mutation which may involve multiple insertions, deletions and substitutions.
Unknown : A mutation with no detailed information available.

I don't what of the characteristics I have to select, probably coding silent, Nonsense, Missense,... any ideas would be helpful

Thanks in advance