Should I use Z-score standardization or Min-Max scaling in biological data ?
Hi, everyone :)
I am always confused about the choise of scale method. For example, when I plot heatmap, I have to make sure the count data are at the same scale, but I do not sure which method I should use, Z-scale or Max-min scale.
So I am wondering whether someone can give some advice about it. I know in the field of machine learning, the choice of scaling method may have some rule of thumb, but I may not sure in biology data, is there some preference ?
Best wishes
Guandong Shang
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z scorewhere as if you want to look at differentially expressed genes you may takenormalizeddataAs usual it depends on the data and the objective. Z-score normalization may be more useful for statistical applications while min-max normalization may be better for visualization. Note that min-max normalization can be problematic if there are outliers.