Hi!

To extend a bit on Pierre's comment:

REST or SOAP?

REST, because you access the API through parametrized URLs. SOAP would have some form of XML message that you need to send, http://en.wikipedia.org/wiki/SOAP.

PathwayCommons API URL

The base URL for making RESTful requests is: http://www.pathwaycommons.org/pc/webservice.do

In order to get the API to do anything, you need to add some arguments to the URL though. For example:

http://www.pathwaycommons.org/pc/webservice.do?cmd=get_pathways&version=2.0&q=O14763&input_id_type=UNIPROT

1. cmd: command for the API
2. version: API version to use, which will be mostly 2.0, but is 3.0 for the command get_neighbors
3. q: I am quoting the documentation here: "a comma separated list of internal or external identifiers (IDs), used to identify the physical entities of interest"
4. input_id_type: the type of IDs you are using; a list of valid IDs is listed here: http://www.pathwaycommons.org/pc/webservice.do?cmd=help#valid_input_id_type

You can execute a query in your BASH as follows:

$ curl -s 'http://www.pathwaycommons.org/pc/webservice.do?cmd=get_pathways&version=2.0&q=O14763&input_id_type=UNIPROT'
Database:ID Pathway_Name    Pathway_Database_Name   CPATH_ID
UNIPROT:O14763  Caspase-8 is formed from procaspase-8   REACTOME    486288
UNIPROT:O14763  TRAIL signaling REACTOME    486289
UNIPROT:O14763  Activation of Pro-Caspase 8 REACTOME    486291
UNIPROT:O14763  Death Receptor Signalling   REACTOME    486300
UNIPROT:O14763  Extrinsic Pathway for Apoptosis REACTOME    486301
UNIPROT:O14763  Apoptosis   REACTOME    486302
...

Language

It is possible to query the API with curl from the command line, or pretty much any programming language which has libraries for making HTTP requests. Here is a simple snippet how to get the same information from above via Ruby. Save the following text as api.rb:

require 'net/http'
require 'uri'

url = URI.parse('http://www.pathwaycommons.org')

res = Net::HTTP.start(url.host, url.port) {|http|
    http.get('/pc/webservice.do?cmd=get_pathways&version=2.0&q=O14763&input_id_type=UNIPROT')
}

puts res.body

Now you can run this Ruby script in your shell as:

ruby api.rb

Hope that helps,

Joachim