Hi there,I am new to biological data analysis,so need some idea and suggestions to solve problems.Hoping for a positive response from all. Thanks in advance.
I need to find 1-to-1 orthologous genes between humans and mouse,using Biomart. Where can I exactly get the section for the same? I can find orthologs but not exactly conserved 1-to-1 orthologs.
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written
by
manishaB •
1 answer
You can get the list of one-to-one orthologous between human and mouse species using Ensembl Biomart as follows:
Go to the https://www.ensembl.org/biomart/martview/. Select Mouse.
For attributes, select
Gene stable ID,Human gene stable IDandHuman homology typeDownload the file as .tsv and filter the rows with homology type as
ortholog_one2one.
This will provide the list of the genes with one to one orthology between mouse and human.
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Once you have the relationships between your genes, just remove the ones that are not one-to-one with a bit of scripting.
If it does not have to be done using BioMart then you can find that information from MGI here.