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Methylation normalization between samples from different platform

hello

i have SARCOMA methylation data from BeadChip platform.

and i found normal methylation data samples in TCGA from Illumina Human Methylation 450.

in minfi package, i try to read data to normalization. However, the error occurs because of different data format.

in this case , how can i normalize it?

gene

1 answer

You cannot. Platforms are too different to be used in the same statistical analysis. Results would be dominated by batch effects rather than biological truth.

sincerely really thank you!!!

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