How to distinguish subclone from sciClone or PyClone result
Hello everyone,
I used sciClone and PyClone to cluster mutations, but don't konw how to distinguish founding clone and subclone. I would really appreciate if someone could answer this question.
• 2,877 views
•
link
written
by
bioxujintian •
1 answer
The founding clone is made up of the set of mutations that is in every cell of the tumor. It generally corresponds to the highest-VAF clone (which should be highest in all samples)
• 0 views
•
link
written
by
Chris Miller
Log in to answer this question.
More posts like this
-
Why only C > A,T,G and T > A,G,C mutations typically considered in 96 SBS context plots
written by BioStar22 •
-
Can genotype PCs from GRCh37 be directly used in GRCH38 situation?
written by shX •
-
Multiple sequence alignment tools
written by Acapmiolo •
-
How can I use rdp classifier method when use pick_open_reference_otus.py
written by bioxujintian •
-
Correcting for tumor purity in tumor evolution analysis
written by cbst
-
Forum: MutSigCV question: Why V1.3 and V1.4 have great different result?
written by bioxujintian •
-
Coverage for de novo genome and transcriptome assembly of unknown size
written by kris_A •
-
How to use MutSigCV correctly
written by bioxujintian •
-
Tumor evolution tool for reconstructing a phylogenetic tree
written by Ikram •
-
Hadoop BAM - how to use?
written by shalini.ravishankar •
Thanks, Miller. Do you mean the highest VAF cluster in a sample is the founding clone in this sample?
Usually that is the case