Hello Shicheng Guo!

We believe that this post does not fit the main topic of this site.

Too broad. It looks like you're asking for a solution custom built for you - you'll need to hire an experienced bioinformatician or contract a company (or use Galaxy if you know how) for this.

For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.

If you disagree please tell us why in a reply below, we'll be happy to talk about it.

Cheers!