I have a normal human embryonic stem cell line (hESC) and the WES data analysis gives me 109313 SNP and 9943 Indel results. Are these numbers normal for a NORMAL cell line? I was thinking since this is a normal cell line it should not have many SNPs. For the SNP calling I used samtools and I did not do any special filtering ( like count of the reads covering the position of the SNP). Should I do some sort of special filtering?