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How to download database of Human protein sequences with sub cellular locations?

How Can I download Human Protein Database for every protein sequence with its sub cellular locations. I know there is this famous site UniProt where all protein database is located and can be downloaded in fasta format. Also at that site there is information of protein sub cellular locations.

Is there some built in tool or I need to write some web crawler for that?

proteins sub cellular locations download human

1 answer

using the uniprot XML dump, an XSL transformation sheet and my program XsltStream: http://lindenb.github.io/jvarkit/XsltStream.html

Hi, in my experience that gets you about half of the the annotations, however the way the web front-end of Uniprot calculates the localization seems more complex. They also calculate a localization for entries without the comment section, solely based on GO terms. So if looking for the 'final verdict' from Uniprot, there is no real solution other than screen-scraping, getting the Uniprot code (would be awesome if this was open-source, not sure why they won't share the code), or parsing GO terms to test if they are derived from the cellular component ontology.

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