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taxa identification using signature vs alignment to refseq

Has anyone tried and compared the taxa identified using both signatures and reference sequences? I seem to identify much more taxa from the refseq with little overlap with what i identified from signatures. In this case, which results should i trust more?

alignment signatures refseq metagenomics
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written by bitpir bitpir

Which do you think is more reliable? A likely (incomplete) signature databases versus experimentally/manually validated RefSeq sequence.

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written by GenoMax GenoMax

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