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Mapping The Specificity Of Gpcrs To G-Proteins

I have a list of GPCRs, and I'd like to determine the G-proteins (Gs, Gi, Gq) to which they bind. In my ideal world, this would be a simple database lookup of experimentally-determined results. But in my searching, I've not found such a database.

Alternatively, I'd be open to computational prediction of G-protein specificity. For example, I've found these two publications:

But it doesn't appear like either of these methods are widely used. Anyone else know of any resources/methods that I should be aware of?

database prediction
• 4,151 views • link
updated by Fred Fleche Fred Fleche • written by Andrew Su Andrew Su

3 answers

You can try to classify your sequences using GPCRpred to identify their family or sub-family information. A webserver is available based on the method. List of related resources are provided in the information page of GPCRpred. If you have large number of sequences, you may request the authors for a Mechanize based access to the server.

If you need a non-prediction based approach, I would recommend you to take a look at the Sevens database or GPCRDB.

• 1 views • link
written by Khader Shameer Khader Shameer

You might find something useful here.

• 3 views • link
updated by Ram Ram • written by Nir London • Nir London

nice collection of links!

• 0 views • link
written by Andrew Su Andrew Su

[?]

http://bioinformatics.biol.uoa.gr/gpDB/ [?]You can also check the additional resources (databases, web servers) provided at the following webpage :[?] http://www.bioinformatics.fr/biology.php?subsection=GPCR

• 1 views • link
written by Fred Fleche Fred Fleche

the interface of gpDB is a bit crude, but the data there is very relevant and useful. Doesn't appear to be an API or download files, but at least I could screen scape if necessary. Thanks!

• 0 views • link
written by Andrew Su Andrew Su

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