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because some extra amino acids could break the conformation of the protein -> active domain is broken.
closing as it's not related to bioinformatics.
Hello Dayna!
We believe that this post does not fit the main topic of this site.
I'm closing this question as it's not related to bioinformatics.
For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.
If you disagree please tell us why in a reply below, we'll be happy to talk about it.
Cheers!
Why a stoploss mutation is not related to bioinformatics? Shouldnot we understand the type of mutations we try to discover from data?
Because it's a basic concept of molecular biology, you would expect to find in good text books on the topic. As a rule of thumb, we do not attempt to explain basic concepts of molecular biology on this site that have better explanation elsewhere.