Dear all , I am working on network based gene expression analysis. Based on network topology measures, I have retrieved hub genes from various sub clusters. For specific biological interpretation, I want to check their importance in terms of their disease specificity. I explored Fundo available at http://fundo.nubic.northwestern.edu/ui/infer which is not working now.
I also tried to use DOSE http://www.bioconductor.org/packages/release/bioc/vignettes/DOSE/inst/doc/semanticAnalysis.html#dosim-function
But there is not any function to change from gene list to disease ontology .
Is there any other way to perform disease ontology based analysis of set of genes ?
Thank you in advance
Archana
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Dear all,
I just found this link https://bioconductor.org/packages/devel/bioc/vignettes/DOSE/inst/doc/enrichmentAnalysis.html#enrichdo-function where gene disease association could be done by using enrichDO function . May be useful for those who are working in this area.
Thank you
thanks for your updates.