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How to get a list of all human protein targets and their target class? UniProt or ChEMBL?

Dear all,

I would like to gain (a) an up-to-date number for all human proteins, (b) the list of all human proteins (and their target classes). My thoughts after googling, searching forum (e.g.https://www.biostars.org/p/2619/) and reading literature are as follows:

I could use ChEMBL to get both a number and a list of all human targets (which have been explored), together with their target classes.

But what happens, when a human protein target has not been explored? I could parse UniProt for more human protein targets, but then I would probably get the different protein modifications of one human protein target, and also, I don't think that I can extract target classes from UniProt.

What would you suggest?

Many thanks for any suggestion! Leanna

chembl uniprot target
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written by Leanna • Leanna

If only it were that easy ....

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written by Leanna • Leanna

2 answers

You can get all human proteins (currently manually validated) from UniProt. There are 20258 as of this writing.

What exactly do you mean by target? You can explore that using OpenTargets or LINK, both from EMBL. There is an API available for OpenTargets to get information programmatically.

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written by GenoMax GenoMax

Dear Genomax,

Many thanks & sorry for the late reply! Your links seem to be what I was looking for!

To clarify a few points:

Again, many thanks!

with best wishes, Leanna

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written by Leanna • Leanna

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