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how can I deal with proteins that belong to one gene if I want to I score my PPI ( Protein Protein subnetwork) according to gene P-value?

I have a list of interested differentially express genes. I integrated my gene with PPI network via using UniProt website http://www.uniprot.org. First, I convert Entrez Genes to UniProtKB then I download the list of targets protein. Then I used this list to get the PPI network.

In the list of targets proteins I have more than one protein for each gene such as:

UniProt      Gene symbol              Gene ID
'B4DNQ5'    'IL6'                       3569
'B4DVM1'    'IL6'                       3569
'B5MC21'    'IL6'                       3569
'P05231'    'IL6'                       3569
'Q75MH2'    'IL6'                       3569

my question is that how can I deal with proteins that belong to one gene if I want to I score my target pathway according to gene P-value??

Any help will be highly appreciated

gene
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written by AAhmed • AAhmed

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