Isn't this insane to do this on metastatic melanoma, a subtype with such high mutation burden? But what can I do except just doing it, because the order is from boss, and communication is impossible.
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haiying.kong
Just tell your boss "yes I can do that, but you should take into account that the results might not be reliable because..."
Such communication is impossible with such dense head, sorry to say this word.
After "because", there will be scientific explanation that involves statistics, and he refuses to hear any bioinformatics, or statistics, or mathematics in any occasion. He is 100000% pure biologist.
Make sure you have it on paper/email that you told him this. As such you are not to blame (?) when things go wrong later on.
Thanks for the advice. If I run, there will be no driver genes identified. So nothing can be included in any paper that can be published. Just waste of my time. But I will keep the email anyway.
Then, he will say: You are making excuse to be lazy!
This will help in getting the blame off you. And then after you can always discuss the reliability or robustness of result later.
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better place to ask ? https://academia.stackexchange.com/questions/tagged/advisor?sort=votes&pageSize=15&mixed=1