I performed an RNAseq experiment and used DESEq2 to calculate statistical significance of differential expression. When I calculated fold change it ranges from 4 fold to 700 fold. I randomly checked few genes showing very high fold change and observed that mostly all the replicates (three) showed good correlation in raw reads in each group and the difference looks reasonably real. However, I dont think any one can show such large fold change in publication or in analysis. . But biologist would like to show FC. I thought about showing log2 ratio but in other comparisons I am showing FC and can not make exception for one comparison. Any suggestion how to tackle such suggestion.