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See these papers:
http://nar.oxfordjournals.org/content/early/2014/11/21/nar.gku1206.full
https://www.semel.ucla.edu/research/variant-filtering-ranking-pipeline
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0480-5
These three consider different problems.
Thank you for the link! It will help me a lot.