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Forum: What are the most important unresolved problems in Bioinformatics?

What are the most important unresolved problems in Bioinformatics?

Is there any problem very important but very challenge? Why it's important? And why it's challenge? For mathematical difficulty, huge computation, or lack of data?

bioinformatics
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updated by Ram Ram • written by chen chen

Writing a specification for the fasta format. :-)

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written by Pierre Lindenbaum Pierre Lindenbaum

Genome assembly specially with highly repetitive regions

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written by Medhat Medhat

Predicting the protein structure from the sequence of the mRNA or the gene.
Predicting relationship between regions of the genome.
Understand the relationship/interaction between miRNA, siRNA, lncRNA, mRNA, rRNA,....
Simulating a live being from birth to death.
Predict interactions of metabolites, proteins or not.

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written by Lluís R. Lluís R.

All encompassing is 'Predicting Phenotype from Genotype or the other way around'.

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written by microfuge microfuge

How to use Excel without getting dates for gene names ;-)

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written by Zaag Zaag

here is a nice article addressing the issue

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written by Prasad Prasad

Combing large datasets from multiple platforms/centers/databases for prediction and inference.

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written by GZ1995 GZ1995

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