Mechanisms of Hypermethylation of CGI in Cancer
Hi All,
Any literature to recommend to answer the question: the mechanism that result in hypermethylation of repressed CGI promoters? Meanwhile, What caused hypo-methylation in non-CGI regions?
Thanks.
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Shicheng Guo
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While someone provides an authoritative answer you can take a look at:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662888/
IMHO, CGI hypermethylation on tumor repressors is largely due to selective adaptation. Can have multiple possible mechanisms including a malfunctioning TET or DNA damage-induced methylation.
nonCGI hypomethylation is mostly due to cell division-induced loss of DNA methylation in cancer.
see for example, http://www.ncbi.nlm.nih.gov/pubmed/23540689